Iron Deprivation Affects Drug Susceptibilities of Mycobacteria Targeting Membrane Integrity
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چکیده
منابع مشابه
Iron Deprivation Affects Drug Susceptibilities of Mycobacteria Targeting Membrane Integrity
Multidrug resistance (MDR) acquired by Mycobacterium tuberculosis (MTB) through continuous deployment of antitubercular drugs warrants immediate search for novel targets and mechanisms. The ability of MTB to sense and become accustomed to changes in the host is essential for survival and confers the basis of infection. A crucial condition that MTB must surmount is iron limitation, during the es...
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Two-component regulatory systems (TCSSs) are key regulatory elements responsible for the adaptation of bacteria to environmental stresses. A classical TCSS is typically comprised of a sensory histidine kinase and a corresponding response regulator. Here, we used homologous recombination to construct a Mycobacterium smegmatis mutant defective in the synthesis of cytosolic histidine kinase PdtaS ...
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By exploiting the biosynthetic pathways of raft lipid constituents, in this study we demonstrate that fluctuations in either sphingolipid or ergosterol levels result in increased drug sensitivity and morphological defects in Candida albicans cells. We show that any change in either ergosterol composition by conditionally disrupting ERG1 or in sphingolipid composition by homozygously disrupting ...
متن کاملSqualene epoxidase encoded by ERG1 affects morphogenesis and drug susceptibilities of Candida albicans.
OBJECTIVES Functional characterization of the erg1 mutant of ergosterol biosynthesis of Candida albicans. METHODS We disrupted the ERG1 gene of C. albicans, which encodes squalene epoxidase (EC 1.14.99.7). Since the disruption of both alleles of ERG1 was lethal, the second allele of a heterozygous disruptant was placed under the control of a regulable promoter, MET3p, which is repressed by me...
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In the present study we have exploited isogenic erg mutants of Saccharomyces cerevisiae to examine the contribution of an altered lipid environment on drug susceptibilities of yeast cells. It is observed that erg mutants, which possess high levels of membrane fluidity, were hypersensitive to the drugs tested, i.e., cycloheximide (CYH), o-phenanthroline, sulfomethuron methyl, 4-nitroquinoline ox...
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ژورنال
عنوان ژورنال: Journal of Pathogens
سال: 2015
ISSN: 2090-3057,2090-3065
DOI: 10.1155/2015/938523